The University of Sydney
Faculty of Pharmacy

Kang Lab

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Dr. Lifeng Kang

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Publications

Contact Information

 

 

 

Journal Papers

2018

1.    Lim SH, Kathuria H, Tan JJY, Kang L (2018) 3D printed drug delivery and testing systems. Advanced Drug Delivery Reviews. DOI: 10.1016/j.addr.2018.05.006. pdf.jpg

 

2.    Tan JJY, Tee JK, Chou KO, Yong SYA, Pan J, Ho HK, Ho PCL, Kang L (2018) Impact of substrate stiffness on dermal papilla aggregates in microgels. Biomaterials Science. 6(6):1347-1357. DOI: 10.1039/c8bm00248g. pdf.jpg

 

3.    Tan JJY, Kang L (2018) Engineering the future of hair follicle regeneration and delivery. Therapeutic Delivery. 9(5), 321每324. DOI: 10.4155/tde-2018-0007. pdf.jpg

4.    Kathuria H, Kochhar JS, Kang L (2018) Micro and nanoneedles for drug delivery and biosensing. Therapeutic Delivery. 9(7), 489 每 492. DOI: 10.4155/tde-2018-0012. pdf.jpg

 

5.    Lim SH, Sun Y, Madanagopal Thiruvallur T, Rosa V, Kang L (2018) Enhanced Skin Permeation of Antiwrinkle Peptides via Molecular Modification. Scientific Report. 8:1596. DOI:10.1038/s41598-017-18454-z. pdf.jpg

 

2017

6.    Ding D, Pan J, Lim SH, Amini S, Kang L, Miserez A (2017) Squid suckerin microneedle arrays for tunable drug release. Journal of Materials Chemistry B. DOI: 10.1039/C7TB01507K. pdf.jpg

 

7.    Tan JJY, Pan J, Sun L, Zhang J, Wu C and Kang L (2017) Bioactives in Chinese proprietary medicine modulates 5a-reductase activity and gene expression associated with androgenetic alopecia. Frontiers in Pharmacology. 8:194. DOI: 10.3389/fphar.2017.00194. pdf.jpg

 

8.    Lim SH, Ng JY, Kang L, Jan 2017. 3-dimensional printing of a microneedle array on personalized curved surface for dual prong treatment of trigger finger. Biofabrication. 9(1):015010. DOI: 10.1088/1758-5090/9/1/015010. pdf.jpg

 

 

2016

9.    Li H, Toh PZ, Tan JY, Zin MT, Lee CY, Li B, Leolukman M, Bao H, Kang L. Nov 2016. Selected biomarkers revealed potential skin toxicity caused by certain copper compounds. Scientific Report. 6:37664. DOI: 10.1038/srep37664. pdf.jpg

 

10. Sun Y, Ruan X, Li H, Du G, Kang L. Nov 2016. Fabrication of non-dissolving analgesic suppositories using 3D printed moulds. International Journal of Pharmaceutics. 513(1-2): 717每724. DOI: 10.1016/j.ijpharm.2016.09.073. pdf.jpg

 

11. Nguyen DV, Jiang S, He C, Lin Z, Lin N, Nguyen AT, Kang L, Han MY, Liu XY. Oct 2016. Elevating biomedical performance of ZnO/SiO2@amorphous calcium phosphate - bioinspiration making possible the impossible. Advanced Functional Materials. 26(38): 6921每6929. DOI: 10.1002/adfm.201601481. pdf.jpg

 

12. Sun Y, Gong X, Tan JY, Kang L, Li D, Vikash, Yang J and Du G. Sep 2016. In vitro antiviral activity of rubia cordifolia aerial part extract against rotavirus. Frontiers in Pharmacology. 7:308. DOI; 10.3389/fphar.2016.00308. pdf.jpg

 

13. Kathuria H, Li H, Pan J, Lim SH, Kochhar JS, Wu C, Kang L. Sep 2016. Large size microneedle patch to deliver lidocaine through skin. Pharmaceutical Research. 33(1): 2653每2667. DOI:10.1007/s11095-016-1991-4. pdf.jpg

 

14. Lim SH, Chia SMY, Kang L, Yap KYL. July 2016. Three-dimensional-printing of carbamazepine sustained-release scaffold. Journal of Pharmaceutical Sciences. 105(7):2155-63. DOI:10.1016/j.xphs.2016.04.031pdf.jpg

 

15. Kang L, Majd S. Apr 2016. Application of Hydrogels in Drug Delivery and Biosensing. Edited book (vol. 3), World Scientific Publishing Co. ISBN: 978-981-3140-41-7 pdf.jpg

 

16. Li H, Bao H, Bok KX, Lee CY, Li B, Zin MT, Kang L. Jan 2016. High durability and low toxicity antimicrobial coatings fabricated by quaternary ammonium silane copolymers. Biomaterials Science. 4:299-309. DOI: 10.1039/C5BM00353Apdf.jpg

 

 

2015

17. Kathuria H, Kochhar JS, Fong MH, Hashimoto M, Iliescu C, Yu H, Kang L. Nov 2015. Polymeric microneedle array fabrication by photolithography. Journal of Visualized Experiment. 105:e52914. DOI: 10.3791/52914. DOI: 10.3791/52914 pdf.jpg

 

18. Kathuria H, Fong MH, Kang L. Aug 2015. Fabrication of photomasks consisting microlenses for the production of polymeric microneedle array. Drug Delivery and Translational Research. 5(4):438-50. DOI: 10.1007/s13346-015-0245-z pdf.jpg

 

19. Li H, Low YSJ, Chong HP, Zin MT, Lee CY, Li B, Leolukman M, Kang L. Aug 2015. Microneedle-mediated delivery of copper peptide through skin. Pharmaceutical Research. 32(8):2678-89. DOI: 10.1007/s11095-015-1652-z pdf.jpg

 

20. Nguyen DV, Li F, Li H, Wong BS, Low CY, Liu XY, Kang L. Feb 2015. Drug permeation through skin is inversely correlated with carrier gel rigidity. Molecular Pharmaceutics. 12(2):444-452. DOI: 10.1021/mp500542a pdf.jpg

 

 

2014

21. Kwan YH, Tung YK, Kochhar JS, Li H, Poh AL, Kang L. Sep 2014. Handbook of Cosmeceutical Excipients. Woodhead Publishing. (Book) Print Book ISBN :9781907568534; eBook ISBN :9781908818713 pdf.jpg

 

22. Kochhar JS, Anbalagan PSO, Shelar SB, Neo JK, Iliescu C, Kang L. Jul 2014. Direct Microneedle Array Fabrication off a Photomask to Deliver Collagen through Skin. Pharmaceutical Research. 31(7):1724-1734. DOI: 10.1007/s11095-013-1275-1 pdf.jpg

 

 

2013

23. Kochhar JS, Li WX S, Zou S, Foo WY, Pan J, Kang L. Nov 2013. Microneedle integrated transdermal patch for fast onset and sustained delivery of lidocaine.  Molecular Pharmaceutics. 2013, 10(11): 4272-4280. DOI: 10.1021/mp400359wpdf.jpg

 

24. Kochhar JS, Quek TC, Soon WJ, Choi J, Zou S, Kang L. Nov 2013. Effect of microneedle geometry and supporting substrate on microneedle array penetration into skin. Journal of Pharmaceutical Science 102(11):4100-4108. DOI: 10.1002/jps.23724 pdf.jpg

 

25. Pan J, Chan SY, Common JEA, Amini S, Miserez A, Lane EB, Kang L. Nov 2013. Fabrication of a 3D hair follicle-like hydrogel mould by soft lithography. Journal of Biomedical Materials Research Part A. 101(11):3159-69. DOI: 10.1002/jbm.a.34628 pdf.jpg

 

26. Kochhar JS, Chan SY, Ong PS, Lee WG, Kang L. Oct 2013. Microfluidics for drug discovery and analysis. Microfluidic Devices for Biomedical Applications. Woodhead Publishing. (Book chapter) DOI : 10.1533/9780857097040.2.231 pdf.jpg

 

27. Yan J, Wong BS, Kang L. Sep 2013. Molecular gel for tissue engineering. Sep 2013. Soft Fibrillar Materials. Wiley.  129-162.  (Book chapter) DOI: 10.1002/9783527648047.ch4 pdf.jpg

 

28. Kang L, Cheong HH, Chan SY, Lim FCP. Sep 2013. Applications of small-molecule gels-drug delivery. Soft Fibrillar Materials. Wiley.  115-128. (Book chapter) DOI: 10.1002/9783527648047.ch3pdf.jpg

 

29. Li H, Yu Y, Dana SF, Li B, Li CY, Kang L. Aug 2013. Novel engineered systems for oral, mucosal and transdermal drug delivery. Journal of Drug Targeting. 21: 611-629. DOI: 10.3109/1061186X.2013.805335 pdf.jpg

 

30. Kang L, Vaddi H K, Lim PFC, Cheong HH, Chan SY. Jul 2013. Terpenes and Improvement of Transdermal Drug Delivery. Handbook of Natural Products. Springer. 3757-3774. (Book chapter) DOI 10.1007/978-3-642-22144-6_160 pdf.jpg

 

31. Faraji-Dana S, Nguyen DV, Kochhar JS, Liu XY, Kang L. Jun 2013. UV-curable pressure sensitive adhesive films: effects of biocompatible plasticizers on mechanical and adhesion properties. Soft Matter.  9:6270-6281. DOI: 10.1039/C3SM50879J pdf.jpg

 

32. Kochhar JS, Goh WJ, Chan SY, Kang L. Feb. 2013. A simple method of microneedle array fabrication for transdermal drug delivery. Drug Development and Industrial Pharmacy. 39:299-309. DOI: 10.3109/03639045.2012.679361pdf.jpg

 

33. Mah CS, Kochhar JS, Ong PS, Kang L. Jan. 2013. A miniaturized flow-through cell to evaluate skin permeation of endoxifen.  International Journal of Pharmaceutics. 441:433-440. DOI: 10.1016/j.ijpharm.2012.11.011 pdf.jpg

 

 

2012

34. Goh WJ, Makam VS, Hu J,  Kang L, Zheng M, Yoong SL, Udalagama CNB, Pastorin G. Dec. 2012. Iron oxide filled magnetic carbon nanotube-enzyme conjugates for recycling of Amyloglucosidase. Langmuir. 28(49):16864-73. DOI: 10.1021/la303046m pdf.jpg

 

35. Wong BS and Kang L. Nov. 2012. Mastery learning in the context of university education. Journal of the NUS Teaching Academy. 2(4), 206-222. pdf.jpg

 

36. Bauer M, Kang L, Qiu Y, (co-first authors), Wu J, Peng M, Chen HH, Camci-Unal G, Bayomy AF, Sosnovik DE, Khademhosseini A, Liao R. Nov. 2012. Adult cardiac progenitor cell aggregates exhibit survival benefit both in vitro and in vivo. PLOS One. 7(11):50491e. DOI: 10.1371/journal.pone.0050491 pdf.jpg

 

37. Wong BS, Teoh SH, Kang L. Aug. 2012. Polycaprolactone scaffold as targeted drug delivery system and cell attachment scaffold for post-surgical care of limb salvage. Drug Delivery and Translational Research. 2:(4) 272-283. DOI: 10.1007/s13346-012-0096-9pdf.jpg

 

38. Kochhar JS, Chan SY, Ong PS and Kang L. Aug. 2012. Clinical therapeutics for phenylketonuria. Drug Delivery and Translational Research. 2:(4) 223-237. DOI: 10.1007/s13346-012-0067-1pdf.jpg

 

39. Kochhar JS, Zou S, Chan SY, and Kang L. Jun. 2012. Protein encapsulation in polymeric microneedles by photolithography. International Journal of Nanomedicine. 7:3143-54. Protein encapsulation in polymeric microneedles by photolithography pdf.jpg

 

 

2011

40. Li H, Jiang B, Yan J, Yang Z, Chen Y, Zhang W, Choy AC, Lee M C-Y and Kang L. A drug-laden elastomer for surgical treatment of anal fistula. Drug Delivery and Translational Research. 2011;1:439-447. (Journal cover) DOI: 10.1007/s13346-011-0044-0 pdf.jpg

 

41. Chourasia MK, Kang L, Chan SY. Nanosized ethosomes bearing ketoprofen for improved transdermal delivery. Results in Pharma Sciences. 2011;1:60-67. DOI: 10.1016/j.rinphs.2011.10.002pdf.jpg

 

42. Pan J, Chan SY, Lee WG, Kang L. Microfabricated particulate drug delivery systems. Biotechnology Journal. 2011;6:1477-1487. DOI: 10.1002/biot.201100237 pdf.jpg

 

43. Li H, Kochhar JS, Pan J, Chan SY, Kang L. Nano/micro-scale technologies for drug delivery. Journal of Mechanics in Medicine and Biology. 2011;11: 337-367. DOI:10.1142/S021951941100406X pdf.jpg

 

 

Before 2011 (Ph.D. and Postdoc)

44. Kang L, Hancock M, Brigham M, Khademhosseini A. Cell confinement within patterned nanoliter droplets in a microwell array. Journal of Biomedical Materials Research: Part A.  2010;93:547-557. DOI: 10.1002/jbm.a.32557 pdf.jpg

 

45. Kachouie N, Kang L, Khademhosseini A. Arraycount, an algorithm for automatic cell counting in microwell arrays. Biotechniques. 2009;47(3):x-xvi. DOI: 10.2144/000113202 pdf.jpg

 

46. Kang L, Chung B, Langer R, Khademhosseini A. Microfluidics for drug discovery and development: From target selection to product lifecycle management. Drug Discovery Today. 2008;13(1-2):1-13. DOI: 10.1016/j.drudis.2007.10.003 pdf.jpg

 

47. Lim PF, Liu XY, Kang L, Ho PC, Chan SY. Physicochemical effects of terpenes on organogel for transdermal drug delivery. International Journal of Pharmaceutics. 2008;358:102-7. DOI: 10.1016/j.ijpharm.2008.02.021 pdf.jpg

 

48. Chung B, Kang L, Khademhosseini A. 2007.  Micro- and nanoscale technologies for tissue engineering and drug discovery applications.  Expert Opinion on Drug Discovery. 2007;2(12):1653-1668. DOI: 10.1517/17460441.2.12.1653 pdf.jpg

 

49. Kang L, Yap CW, Lim PF, Chen YZ, Ho PC, Chan YW, Wong GP, Chan SY. Formulation development of transdermal dosage forms: Quantitative structure-activity relationship model for predicting activities of terpenes that enhance drug penetration through human skin.  Journal of Controlled Release. 2007;31(3):211-219. DOI: 10.1016/j.jconrel.2007.05.006 pdf.jpg

 

50. Kang L, Poh AL, Fan SK, Ho PC, Chan YW, Chan SY. Reversible effects of permeation enhancers on human skin. European Journal of Pharmaceutics & Biopharmaceutics. 2007;67(1):149-55. DOI: 10.1016/j.ejpb.2006.12.010 pdf.jpg

 

51. Lim FC P, Liu XY, Kang L, Ho PC, Chan YW, Chan SY. 2006. Limonene GP1/PG organogel as a vehicle in transdermal delivery of haloperidol.  International Journal of Pharmaceutics 2006;311:157-164. DOI: 10.1016/j.ijpharm.2005.12.042pdf.jpg

 

52. Kang L, Ho PC, Chan SY. Interactions between a skin penetration enhancer and the main components of human stratum corneum lipids isothermal titration calorimetry study. Journal of Thermal Analysis and Calorimetry 2006;83:27-30. DOI: 10.1007/s10973-005-7050-8 pdf.jpg

 

53. Kang L, Liu XY, Sawant PD, Ho PC, Chan YW, Chan SY. SMGA gels for the skin permeation of haloperidol. Journal of Controlled Release 2005;106:89-98. DOI: 10.1016/j.jconrel.2005.04.017 pdf.jpg

 

 

Patent applications

54. Kang L, Chan SY, Kochhar JS, Goh WJ. 2013. A novel method to fabricate polymeric microneedles. ( WIPO WO/2013/137831 )

a.    US 61/611,603, EXPIRED after conversion into PCT application

b.    PCT/SG2013/000108, EXPIRED after entering national stage filing

c.    Singapore 1201405643R, Pending

d.    China 201380025634.6, Pending

e.    United States 14/385,236, Pending

 

55. Kang L, Kochhar JS, Mah CS. 2014. A miniaturized flow-through Cell (MFtC) for testing the permeation of drugs across biological membranes. (WIPO 20140102177 )

 

56. US  61/712,903, EXPIRED after conversion into non-provisional US & SG applications

a.    Singapore 201307640, Pending

b.    United States, 14/051,720, Pending

 

57. Kang L, Ng JY, Lim SH. 2016. Structure for Transdermal Drug Delivery to a Subject and Method of Fabricating the Structure.

a.    Singapore 10201605536T, Pending

 

 

News reports from Singapore and International Media

 

***  Microneedles  ***

58. The Straits Times, 6 September 2014, Home, pB15

NUS team pioneers pain-free injections
Link to pdf version available here

59. Lianhe Zaobao, 6 September 2014, p10

Singapore develops microneedle patch for painless drug delivery
Link to pdf version available here

 

60. The New Paper, 6 September 2014, p4

Pain­free injections soon a reality

Link to pdf version available here

 

61. Shin Min Daily News, 6 September 2014, p8

Microneedle patch enables drugs to be delivered deeper into skin

Link to pdf versiob available here

 

62. Channel NewsAsia, 5 September 2014
Delivering painkillers faster with microneedle patch

 

63. Suria TV News, 5 September 2014

Delivering painkillers faster with microneedle patch

Link to online video available here

 

64. Vasantham TV News, 5 September 2014

Delivering painkillers faster with microneedle patch

 

65. 938LIVE, 5 September 2014

Delivering painkillers faster with microneedle patch

 

66. Capital Radio 95.8FM, 5 September 2014
Microneedle patches

67. Warna 94.2FM, 5 September 2014

Delivering painkillers faster with microneedle patch

 

68. XinMSN, 5 September 2014
Delivering painkillers faster with microneedle patch

 

69. Reuters,

Microneedle patch promises painless pricks

Link to online article available here

 

70. Asia Times Sabah, 6 September 2014, p6

Singapore researchers invent microneedle patch for better delivery of drug

Link to pdf version available here

 

71. The Malaysian Times, 6 September 2014

Delivering painkillers faster with microneedle patch

Link to online article available here

 

72. Medical Design Technology, 5 September 2014
Novel microneedle patch offers faster and effective delivery of painkiller and collagen

Link to online article available here

 

73. Science Daily, 5 September 2014

Novel microneedle patch for faster, effective delivery of painkiller, collagen
Link to online article available here

 

74. Design Products & Applications, 5 September 2014

Novel microneedle patch offers fast and effective drug delivery
Link to online article available
here

 

75. Medical Xpress, 5 September 2014
Researchers invent novel microneedle patch for faster and effective delivery of painkiller and collagen
Link to online article available
here

 

 

***  Cosmeceuticals  ***

 

76. Channel 8 Hello Singapore - 25 Nov, 2 Dec and 9 Dec 2014

Episode 1 (33mins onwards)

Episode 2 (10:30mins onwards)

Episode 3 (33mins onwards)

 

77. The Straits Times, 11 Dec 2014, Home, pB4

NUS study of cosmetics more than skin deep

Link to online article available here

 

78. Lianhe Zaobao, 11 Dec 2014, p8

NUS researcher: Many cosmeceutical excipients to be studied

Link to online article available here

 

79. National University of Singapore

Know your cosmeceuticals

Link to online article available here

 

 

***  A study trip  ***

 

80. Lianhe Zaobao, 28 Jan 2015, P9

NUS pharmacy students having learning and exchange in China

Link to online article available here

 

Kang Lab, Pharmacy and Bank Building A15, Science Road, University of Sydney, NSW 2006, Australia